Key Publications
Staels W, Berthault C, Bourgeois S, Laville V, Lourenço C, De Leu N, Scharfmann. Comprehensive alpha, beta, and delta cell transcriptomics reveal an association of cellular aging with MHC class I upregulation.
Mol Metab. 2024 Jul 14:87:101990.
Bourgeois S, Coenen S, Degroote L, Willems L, Van Mulders A, Pierreux J, Heremans Y, De Leu N, Staels W. Harnessing beta cell regeneration biology for diabetes therapy.
Trends Endocrinol Metab. 2024 Apr 20
Staels W, Verdonck Y, Heremans Y, Leuckx G, De Groef S, Heirman C, de Koning E, Gysemans C, Thielemans K, Baeyens L, Heimberg H, De Leu N: Vegf-A mRNA transfection as a novel approach to improve mouse and human islet graft revascularisation.
Diabetologia 61(8), 1804-1810, 2018
Staels W, Heremans Y, Leuckx G, Van Gassen N, Salinno C, De Groef S, Cools M, Keshet E, Dor Y, Heimberg H, De Leu N: Conditional islet hypovascularisation does not preclude beta cell expansion during pregnancy in mice.
Diabetologia 60(6), 1051-1056, 2017
Yuchi Y, Cai Y, Legein B, De Groef S, Leuckx G, Coppens V, Van Overmeire E, Staels W, De Leu N, Martens G, Van Ginderachter JA, Heimberg H, Van de Casteele M: Estrogen Receptor α Regulates β-Cell Formation During Pancreas Development and Following Injury.
Diabetes 64:3218-3228, 2015
Van de Casteele M, Leuckx G, Cai Y, Yuchi Y, Coppens V, De Groef S, Van Gassen N, Baeyens L, Heremans Y, Wright CV, Heimberg H: Partial duct ligation: β-cell proliferation and beyond.
Diabetes 63:2567-2577, 2014
D'Hoker J, De Leu N, Heremans Y, Baeyens L, Minami K, Ying C, Lavens A, Chintinne M, Stangé G, Magenheim J, Swisa A, Martens G, Pipeleers D, Van de Casteele M, Seino S, Keshet E, Dor Y, Heimberg H: Conditional hypovascularization and hypoxia in islets does not overtly influence adult beta cell mass and function.
Diabetes 62:4165-4173, 2013
Xu X, D'Hoker J, Stangé G, Bonné S, De Leu N, Xiao X, Van De Casteele M, Mellitzer G, Ling Z, Pipeleers D, Bouwens L, Sharfmann R, Gradwohl G, Heimberg H: Beta cell progenitors can be generated from endogenous progenitors in injured adult mouse pancreas.
Cell 132:197-207, 2008
Mellitzer G, Bonné S, Luco, RF, Van De Casteele, M, Lenne, N, Collombat, P, Mansouri, A, Lee J, Lan M, Pipeleers D, Nielsen FC, Ferrer J, Gradwohl G. and Heimberg H.: IA1 is Ngn3-dependent and essential for differentiation of the endocrine pancreas.
EMBO J 25:1344-1352, 2006
Heremans Y, Van De Casteele M, in 't Veld P, Gradwohl G, Serup P, Madsen O, Pipeleers D, Heimberg H: Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3.
J Cell Biol 159:303-311, 2002
Heimberg H, Bouwens L, Heremans Y, Van De Casteele M, Lefebvre V, Pipeleers D: Adult human pancreatic duct and islet cells exhibit similarities in expression and differences in phosphorylation and complex formation of the homeodomain protein Ipf-1.
Diabetes 49:571-579, 2000
Heimberg H, De Vos A, Moens K, Quartier E, Bouwens L, Pipeleers D, Van Schaftingen E, Madsen O, Schuit F: The glucose sensor protein glucokinase is expressed in glucagon-producing alpha-cells.
Proc Natl Acad Sci USA 93:7036-7041, 1996
Devos A, Heimberg H, Quartier E, Huypens P, Bouwens L, Pipeleers D, Schuit F: Human and Rat Beta-Cells Differ in Glucose-Transporter but Not in Glucokinase Gene-Expression.
J Clin Invest 96:2489-2495, 1995
Heimberg H, De Vos A, Vandercammen A, Vanschaftingen E, Pipeleers D, Schuit F: Heterogeneity in Glucose Sensitivity among Pancreatic Beta-Cells Is Correlated to Differences in Glucose Phosphorylation Rather Than Glucose- Transport. EMBO J 12:2873-2879, 1993
